chuka_lis (chuka_lis) wrote,
chuka_lis
chuka_lis

Потеря костной плотности и массы

Эксперимент с заражением ковидом хомячков выявил, что при ковиде поражаются не только легкие.
Исследователи отметили  резорбцию костной ткани (в длинных костях и позвоночник)  при воспалительных процессах, вызванных болезнью. Причем не только во время болезни, но и продолжающиеся ухудшения плотности кости после выздоровления.
Что особенно неприятная новость для пожилых (тк возможен системный остеопороз, и переломы- как факторы риска после ковида).
Потому такие возможные осложения после ковида- нужно мониторить.

Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone loss. In this study, we characterized the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on bone metabolism in an established golden Syrian hamster model for COVID-19. SARS-CoV-2 causes significant multifocal loss of bone trabeculae in the long bones and lumbar vertebrae of all infected hamsters. The bone loss progressively worsens from the acute phase to the post-recovery phase. Mechanistically, the bone loss was associated with SARS-CoV-2-induced cytokine dysregulation which upregulates osteoclastic differentiation of monocyte-macrophage lineage. The pro-inflammatory cytokines further trigger a second wave of cytokine storm in the skeletal tissues to augment their pro-osteoclastogenesis effect. Our findings in this established hamster model suggest that pathological bone loss may be a neglected complication which warrants more extensive investigations during the long-term follow-up of COVID-19 patients. The benefits of potential prophylactic and therapeutic interventions against pathological bone loss should be further evaluated.

Tags: болезнь, коронавирус, статьи
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