Another interesting pattern observed in the training set was a group of Bat SARS-like and MERS-like viruses that were routinely classified as human pathogens–specifically, members of Jinning mine group of viruses such as Rs4231 and Rs4874, as well as the MERS-likes NL13845 and NL140422 sampled from a cave in Guangdong (30,31). These class designations seem to be supported by serological evidence of positivity to SARS-likes reported in the area surrounding the Jinning cave from which these SARS-like viruses were sampled (30). Finally, human enteric coronavirus 4408 was classified as a non-human pathogen in 35 of the 45 trained models, including those that were 100% accurate on the test set.
The models also appear to describe a human-pathogen class definition that only includes viruses that can readily transmit between adults. There are now a series of coronaviruses that appear to have the capability to cause clinical illness in children, butthe children act as terminal hosts for the virus. This list now includes Canine Alphacoronaviruses observed in Thailand in 2007 (43)and Malaysia in 2018(33), Murine HepatitisVirus detected in SRA datasets from children with febrile illness(44), Porcine Deltacoronaviruses in children in Haiti in 2014 and 2015(45), as well as human enteric coronavirus 4408(32).