Introduction Long COVID, describing the long-term sequelae after SARS-CoV-2 infection, remains a poorly defined syndrome. There is uncertainty about its predisposing factors and the extent of the resultant public health burden, with estimates of prevalence and duration varying widely. Methods Within rounds 3–5 of the REACT-2 study, 508,707 people in the community in England were asked about a prior history of COVID-19 and the presence and duration of 29 different symptoms. We used uni- and multivariable models to identify predictors of persistence of symptoms (12 weeks or more). We estimated the prevalence of symptom persistence at 12 weeks, and used unsupervised learning to cluster individuals by symptoms experienced. Results Among the 508,707 participants, the weighted prevalence of self-reported COVID-19 was 19.2% (95% CI: 19.1,19.3). 37.7% of 76,155 symptomatic people post COVID-19 experienced at least one symptom, while 14.8% experienced three or more symptoms, lasting 12 weeks or more. This gives a weighted population prevalence of persistent symptoms of 5.75% (5.68, 5.81) for one and 2.22% (2.1, 2.26) for three or more symptoms. Almost a third of people 8,771/28,713 (30.5%) with at least one symptom lasting 12 weeks or more reported having had severe COVID-19 symptoms (“significant effect on my daily life”) at the time of their illness, giving a weighted prevalence overall for this group of 1.72% (1.69,1.76). The prevalence of persistent symptoms was higher in women than men (OR: 1.51 [1.46,1.55]) and, conditional on reporting symptoms, risk of persistent symptoms increased linearly with age by 3.5 percentage points per decade of life. Obesity, smoking or vaping, hospitalisation , and deprivation were also associated with a higher probability of persistent symptoms, while Asian ethnicity was associated with a lower probability. Two stable clusters were identified based on symptoms that persisted for 12 weeks or more: in the largest cluster, tiredness predominated, while in the second there was a high prevalence of respiratory and related symptoms. Interpretation A substantial proportion of people with symptomatic COVID-19 go on to have persistent symptoms for 12 weeks or more, which is age-dependent. Clinicians need to be aware of the differing manifestations of Long COVID which may require tailored therapeutic approaches. Managing the long-term sequelae of SARS-CoV-2 infection in the population will remain a major challenge for health services in the next stage of the pandemic.
Женщины болеют в 1.5 раз чаще. 38% из болеющих пост-ковидом имеют хотя б один из 29 симптомов долгого ковида, 15%- три и более симптома.
Каждые 10 лет возраста увеличивают шансы попасть в когорту долгоковидных на 3.5%.
Треть долгоковидных имеет постковидные симптомы, ассоциированные с тяжелым течением ковида (одышка, тяжесть и боль в груди, этс), около 60%- симптомы, похожие на синдром хронической усталости.
More than 2 million adults in England have experienced coronavirus symptoms lasting over 12 weeks, government data suggests – double the previous estimate for long Covid.The study, one of the largest to date, found that people with ongoing symptoms tended to fall into two categories: those with respiratory symptoms, who often experienced more severe illness when they first got sick, and a second group with fatigue-related symptoms.The research, which has not yet been peer-reviewed, found that 37.7% of those who had symptomatic Covid experienced at least one symptom lasting 12 weeks or more – equivalent to 2 million people – while 14.8% experienced three or more persistent symptoms. In May the Office National Statistics (ONS) estimated that 1 million people in the UK were experiencing self-reported long Covid. A key difference is that React-2 did not ask if people had long Covid, only about ongoing symptoms. “Many people may not consider they’ve got long Covid, they just have a persistent slight shortness of breath, or their loss of sense of taste has persisted for many, many months,” said Helen Ward, professor of public health at Imperial College London, who co-led the study
The React-2 study also found that the prevalence of persistent symptoms increased with age, with a 3.5% increase in the likelihood of developing long Covid for each decade of life. Women were 1.5 times more likely to experience ongoing symptoms than men
Meanwhile, a separate study of 312 Norwegian patients published in Nature Medicine on Wednesday found that 61% were still experiencing persistent symptoms at six months – including 52% of 16-30-year-olds. The most common symptoms they reported were loss of taste and/or smell and tiredness.
Скорее всего, в других странах расклад примерно такой же.