chuka_lis (chuka_lis) wrote,
chuka_lis
chuka_lis

Изотипы антител в динамике

Другая статья по иммунологии ковида, тоже интересная, и, в принципе- в ту же копилку, что и предыдущая публикация.
О том, что иммунный ответ отличается на разные антигены вируса и по разными типам продуцируемых  антител, в зависимости от времени с начала инфекции и типа течения болезни.
Авторы рекомендуют проводить серологические тесты больным и использовать обнаруживаемые ранние высокие уровни антител к рецептор-связывающей части шипикового белка коронавируса  как индикатор тяжелой болезни.
Предположу, чтоб пораньше давать иммуносупрессанты (а что еще можно сделать).

This study aimed to investigate the kinetics and neutralizing activity of various antigen-specific antibody isotypes against SARS-CoV-2 in serum of coronavirus disease 2019 (COVID-19) patients confirmed via polymerase chain reaction test. We developed IgG, IgM and IgA measurement assays for each antigen, including receptor-binding domain (RBD) of spike (S) protein, S1 domain, full length S protein, S trimer and nucleocapsid (N) domain, based on enzyme-linked immunosorbent assay. The assays of the S protein for all isotypes showed high specificity, while the assays for all isotypes against N protein showed lower specificity. The sensitivity of all antigen-specific antibody isotypes depended on the timing of the serum collection and all of them, except for IgM against N protein, reached more than 90% at 15-21 days post-symptom onset. The best correlation with virus neutralizing activity was found for IgG against RBD (RBD-IgG), and levels of RBD-IgG in sera from four severe COVID-19 patients increased concordantly with neutralizing activity. Our results provide valuable information regarding the selection of serological test for seroprevalence and vaccine evaluation studies.
Relationship between RBD-IgG production and disease severity.
Serum RBD-IgG levels (.. which was the best indicator of neutralizing activity)  in severe COVID-19 patients were significantly higher than non-severe cases as early as 8–14 days after symptom onset, while severe COVID-19 patients produced high levels of RBD-IgG over time.
As shown.. serum RBD-IgG in all four patients increased over time, in concordance with virus neutralizing activity.
Tags: иммунитет, коронавирус, статьи
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